Development and production of veterinary antibiotics
Office 11, Narodny boulevard, 92, Belgorod, 308000, Russia.
Active substances:
Powder for oral administration is prescribed to calves, pigs, fur-bearing animals, dogs and cats for a preventive and therapeutic purposes against:




diseases of the genitourinary system and other infections of bacterial etiology;

respiratory mycoplasmosis in chickens. 
For the treatment of gastrointestinal and respiratory diseases of bacterial etiology in animals.
tetracycline - 12.5%,

rifampicin - 3%,

vitamins B1 - 0.05%, B2 - 0.05%. 
1. Trade name of the drug: Rivicyclinum A International nonproprietary names of active substances: tetracycline, rifampicin, vitamins B1 (thiamine) and B2 (riboflavin).

2. Pharmaceutical dosage form: powder for oral administration. Rivicyclinum A contains as active ingredients: tetracycline-12.5%, rifampicin - 3%, vitamins B1 - 0.05% and B2 - 0.05%, and as an auxiliary substance: lactose - up to 100%. In appearance, the drug is a fine loose powder of orange to red-brown color; when mixed with water, forms a suspension.

3. Rivicyclinum A is produced packaged in 50, 100, 200, 500 and 1,000 g double plastic bags or in bags made of paper with a polyethylene coating; in 90g and 450g polymer cans.

4. Rivicyclinum A should be stored in manufacturer’s sealed packaging, separately from food and feed, in a dry place protected from direct sunlight, at temperatures from 5 °C to 25 °C. Shelf life with the storage conditions observed is 2 years from the date of manufacture. It is forbidden to use Rivicyclinum A after the expiration date.

5. Rivicyclinum A should be kept out of the reach of children.

6. Unused medication should be disposed of in accordance with legal requirements. 
7. Rivicyclinum A is a combined antibacterial preparation. The tetracycline inside the drug has a wide spectrum of antimicrobial effects, is active against most gram-positive and gram-negative microorganisms, including streptococci, staphylococci, escherichia, salmonella, bordetella, as well as some protozoa, rickettsia and chlamydia. The mechanism of action of tetracycline is based on the suppression of protein synthesis in the microbial cell at the ribosomal level. After oral administration of the drug, tetracycline is easily absorbed and penetrates into most organs, tissues and biological fluids of the body, selectively accumulates in the bones, liver, spleen, teeth, and is partially metabolized in the liver. Tetracycline is eliminated mainly by the kidneys, and in smaller amounts with bile into the intestine, where partial reverse absorption occurs, contributing to the prolonged circulation of the active substance inside the body.

Rifampicin is a semi-synthetic antibiotic of the anzamycin group, it is active mainly against gram-positive bacteria, in low concentrations it affects staphylococci, including those resistant to other antibiotics, in high concentrations it also affects a number of gram-negative microorganisms, including escherichia, klebsiella, proteus and mycobacteria. The bactericidal effect of rifampicin is based on the selective inhibition of DNA-dependent RNA polymerase in a microbial cell. The antibiotic is well absorbed in the digestive tract, easily penetrates into organs and tissues, and is metabolized (about 25%) with the formation of inactive metabolites, excreted mainly with bile, and partially with urine. Peak concentrations of tetracycline and rifampicin in blood plasma are observed in 2-2.5 hours after oral administration of the drug; therapeutic concentrations are maintained for up to 24 hours. Vitamins B1 (thiamine) and B2 (riboflavin) are involved in many enzyme reactions, in carbohydrate, protein and fat metabolism, and inactivate and oxidize toxic products formed during the life of bacteria. Rivicyclinum A by its degree of exposure to the body belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007). 
8. Rivicyclinum A is prescribed for treatment of colibacteriosis, salmonellosis, gastroenterocolitis, bronchopneumonia in calves, piglets, fur-bearing animals, dogs and cats, as well as colibacteriosis, mycoplasmosis in chicks and the other animal diseases with pathogens sensitive to the drug.

9. A contraindication to the use of Rivicyclinum A is the individual hypersensitivity of the animal to the components of the drug. It is forbidden to give Rivicyclinum A to laying hens due to the accumulation of the drug in eggs. The drug should not be administered to adult cattle with advanced ruminal digestion, animals with severe renal failure, or females in the first third of pregnancy.

10. Rivicyclinum A should be administered to calves and suckling pigs individually orally with drinking water for 5-7 days: in case of gastrointestinal diseases at a dose of 200-300 mg/kg of animal weight 2 times a day or 300 mg/kg of animal weight once every day; in case of respiratory diseases, at a dose of 200-300 mg/kg 2 times a day. For piglets of older ages, the drug should be administered in a mixture with feed at the rate of 4-5 kg per ton of feed for 5-7 days. For fur-bearing animals, cats and dogs, the drug should be administered in a mixture with feed at the rate of 300-450 mg/kg of animal weight 2 times a day for 5-7 days. For chicks, the drug should be administered in a group method with feed at the rate of 4-6 kg per ton of feed or 300-450 mg/kg of bird weight for 5-7 days.

11. In case of drug overdose, the animal may experience a decrease in appetite, depression, vomiting, diarrhea.

12. No specific features of the action of the drug at its first use and cancellation have been revealed.

13. Missing the doses of the drug should be avoided, as this can lead to a decrease in therapeutic effectiveness. If one dose is missed, the use of the drug should be resumed in the same dosage and according to the same scheme.

14. As a rule, there are no side effects and complications when using the Rivicyclinum A in accordance with this instructions. With increased individual sensitivity of the animal to the components of the drug and the appearance of allergic reactions, its use must be discontinued, and the animal must be prescribed antihistamines and symptomatic therapy. In young animals, the use of tetracycline group preparations during tooth growth may cause changes in enamel color.

15. The simultaneous use of Rivicyclinum A with corticosteroids, estrogens, oral anticoagulants and bacteriostatic antibiotics is not allowed in view of the possible decrease in their activity, as well as in conjunction with drugs and feed additives containing magnesium, aluminum and calcium cations, which, when bound to active components of the drug, inhibit their adsorption.

16. Slaughter of calves, piglets and chicks for meat is allowed no earlier than 10 days after the last use of Rivicyclinum A. Meat of animals, forcedly slaughtered before the expiration of the indicated periods can be used as feed for fur-bearing animals. 
17. All work with Rivicyclinum A should be carried out with the use of protective clothing and personal protective means (rubber gloves, goggles, respirator). It is forbidden to drink, smoke or eat while performing work. Face and hands should be washed with soap, and the mouth should be rinsed at finishing the work.

18. People with hypersensitivity to the drug components should avoid direct contact with Rivicyclinum A. In case of accidental ingestion of the drug into the human body or in case of allergic reactions, it is necessary to contact the medical institution immediately (with the instructions for use or a label in hand). Empty containers of the drug must not be used for household purposes. 
I. General information:
II. Pharmacological properties
III. Administration procedure
IV. Personal prevention measures
Rivicyclinum A
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Development and production of veterinary antibiotics
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